| 三联疗法治疗磺酰脲类药物继发失效2型糖尿病的临床观察 |
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| 引用本文： | 孙洪全,李振强. 三联疗法治疗磺酰脲类药物继发失效2型糖尿病的临床观察[J]. 中国药房, 2011, 0(28): 2619-2620 |
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| 作者姓名： | 孙洪全 李振强 |
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| 作者单位： | 山东青岛疗养院药剂科;山东青岛市市立医院内科; |
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| 摘 要： | 目的:观察甘精胰岛素、瑞格列奈、罗格列酮联合治疗磺酰脲类药物继发失效(SFS)的2型糖尿病(T2DM)患者的血糖(BG)控制和胰岛B细胞功能恢复情况。方法:选择26例三联疗法治疗的SFS患者,采用自身前、后对照观察空腹血糖(FPG)、餐后2 h血糖(2hPG)、空腹基础C肽值(FC-P)、餐后2hC肽值(2hC-P)、糖化血红蛋白(HbA1c)等变化。结果:与治疗前比较,甘精胰岛素、瑞格列奈、罗格列酮联合治疗SFS的T2DM,BG控制理想,胰岛B细胞功能改善均有统计学意义(P<0.05)。结论:甘精胰岛素、瑞格列奈、罗格列酮三联疗法能有效控制SFS的T2DM患者BG,并能改善胰岛B细胞功能。
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| 关 键 词： | 磺酰脲类药物继发失效 2型糖尿病 三联疗法 |
Clinical Observation of Triple Therapy in the Treatment of Type 2 Diabetes with Secondary Failure of Sulphonylureas |
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| SUN Hong-quan LI Zhen-qiang. Clinical Observation of Triple Therapy in the Treatment of Type 2 Diabetes with Secondary Failure of Sulphonylureas[J]. China Pharmacy, 2011, 0(28): 2619-2620 |
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| Authors: | SUN Hong-quan LI Zhen-qiang |
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| Affiliation: | SUN Hong-quan(Dept.of Pharmacy,Qingdao Sanatorium of Shandong Province,Qingdao 266071,China) LI Zhen-qiang(Internal Medicine of Qingdao Municipal Hospital,Qingdao 266011,China) |
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| Abstract: | OBJECTIVE: To observe the blood glucose control and improvement of B-CF in type 2 diabetes(T2DM) patients with secondary failure of sulphonylureas(SFS) treated with combination therapy of glargine insulin,repaglinide and rosiglitazone.METHODS: A total of 26 T2DM patients with SFS received triple therapy.The changes of fasting blood glucose(FBG),2-hour postprandial blood glucose(2hBG),fasting C-peptide(FC-P),2-hour postprandial C-peptide(2hC-P) and homoglobin A1c(HbA1c) were observed in self control study.RE... |
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| Keywords: | Secondary failure of sulphonylureas Type 2 diabetes Triple therapy |
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