N-acetyltransferase 2 (NAT2) gene polymorphisms in Parkinson's disease |
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| Authors: | Juergen Borlak Stella Marie Reamon-Buettner |
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| Institution: | (1) Drug Research and Medical Biotechnology, Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai-Fuchs-Strasse 1, 30625 Hannover, Germany;(2) Chair in Pharmaco-and Toxicogenomics, Center of Pharmacology and Toxicology, Medical School Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany |
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| Abstract: | Background Parkinson's disease (PD) is a movement disorder caused by the degeneration of dopaminergic neurons in the substantia nigra
of the midbrain. The molecular basis of this neural death is unknown, but genetic predisposition and environmental factors
may cause the disease. Sequence variations in N-acetyltransferase 2 (NAT2) gene leading to slow acetylation process have been associated with PD, but results are contradictory. |
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