TRAIL与甲状腺疾病的相关性研究进展

肿瘤坏死因子相关凋亡诱导配体(TRAIL)是近年来新发现的凋亡因子,参与机体的免疫调节、免疫自稳及免疫监视,在多种自身免疫性疾病中表达异常。越来越多的证据显示,凋亡在自身免疫性及增殖性甲状腺疾病的发病机制中发挥了重要作用,而且其凋亡的路径是复杂且高度调控的。TRAIL可以选择性地杀伤肿瘤细胞和病毒感染的细胞,而正常细胞则通过表达诱骗受体等方式逃逸其杀伤作用,这种特性使其在肿瘤治疗应用中具有巨大潜力。

Adrance of Reserch on relationship between TRAIL and Thyroid Diseases

Tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)was an apoptosis factor discovered recently,involved in immune regulation,immune homeostasis and immune surveillance,expressed abnormally in a variety of autoimmune diseases.More and more evidence showed that apoptosis played an important role in autoimmune or proliferative thyroid disease,and the path of apoptosis was complex and highly regulated.TRAIL can selectively kill tumor cells and virus-infected cells,while normal cells through means of expressing decoy receptors and escape the killing effect.Such characteristics made it has great potential in therapy of cancer.