Epstein-Barr virus-associated gastric carcinoma in Kazakhstan |
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Authors: | Alipov Gabit Nakayama Toshiyuki Nakashima Masahiro Wen Chun-Yang Niino Daisuke Kondo Hisayoshi Pruglo Yuri Sekine Ichiro |
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Affiliation: | 1. Tissue and Histopathology Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute,Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan 2. Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan 3. Biostatics Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences,Nagasaki,Japan 4. Department of Pathology, Semipalatinsk Medical Academy, Semipalatinsk, Kazakhstan 5. Tissue and Histopathology Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute,Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan;Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan |
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Abstract: | AIM: To investigate the incidence of Epstein-Barr virus-associated gastric cancer (EBV-GC) in Kazakhstan and to compare it with that in Russia, Western and Asian countries in order to evaluate the significance of epidemiopathologic and ethnic factors. METHODS: In situ hybridization (ISH) of EBV-encoded small RNA-1 (EBER-1) was used to identify the presence of EBER-1 signal in 139 formalin-fixed and paraffin-embedded GC tissues from Kazakhstan. RESULTS: EBER-1 expression was observed in the nuclei of 10% of the cases of GC (14/139), but not in the surrounding normal mucosa. The incidence of the diffuse type of EBV-GC was significantly higher in Kazakhstan (14%, 13/91) than that of the intestinal type (2%, 1/48). Furthermore, the incidence was significantly higher in males (14%, 12/89) than in females (3.7%, 2/53) from all countries. The overall incidence of EBV-GC increased from 6.7% in Asian countries to 8.7% in Russia, 10.1% in Kazakhstan and 16% in Western countries. CONCLUSION: Geographical differences in the incidence of EBV-GC may reflect the epidemiologic factors and/or dietary habits independent of histological type and sex. |
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Keywords: | Gastric carcinomas Epstein-Barr virus EBV-encoded small RNA-1 |
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