Urinary zinc excretion and acute phase response in cancer patients |
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| Authors: | B. Melichar P. Jandik M. Tichy F. Malir J. Mergancova Z. Voboril |
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| Affiliation: | (1) Second Department of Internal Medicine, Charles University Medical School, Pospisilova 365, CZ-500 36 Hradec Kralove, Czech Republic;(2) Department of Surgery, Charles University Medical School, Pospisilova 365, CZ-50036 Hradec Kralove;(3) Xenobiochemic Laboratory, Regional Hygiene Station, Hradec Kralove, Czech Republic |
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| Abstract: | We investigated urinary zinc and serum levels of C-reactive protein, alpha-1 acid glycoprotein, haptoglobin, transferrin and prealbumin in 55 patients with solid tumors and 20 controls. Urinary zinc, serum C-reactive protein, alpha-1 acid glycoprotein and haptoglobin were significantly higher, and serum prealbumin was significantly lower in cancer patients. A significant positive correlation between urinary zinc and C-reactive protein, alpha-1 acid glycoprotein and haptoglobin, as well as a negative correlation with transferrin and prealbumin were observed. Hyperzincuria in cancer patients appears to be linked to the acute phase response. Our data provide further evidence implicating systemic inflammatory response in increased urinary zinc excretion.Correspondence to: B. Melichar |
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| Keywords: | Acute phase response Alpha-1 acid glycoprotein Cancer C-reactive protein Haptoglobin Prealbumin Transferrin Urine zinc |
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