| 雌激素对大鼠部分肝缺血再灌注损伤的影响 |
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| 引用本文： | 闫凤霞,刘艳华,王艳辉,孙阁,袁亚非. 雌激素对大鼠部分肝缺血再灌注损伤的影响[J]. 承德医学院学报, 2006, 23(3): 229-231 |
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| 作者姓名： | 闫凤霞 刘艳华 王艳辉 孙阁 袁亚非 |
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| 作者单位： | 承德医学院机能实验学教研室,河北,承德,067000 |
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| 摘 要： | 目的:观察雌激素在大鼠部分肝缺血再灌注损伤中的作用.方法:60只SD大鼠随机分为雌性组(F组)、雄性组(M组)、雌性卵巢切除组(O组)、雄性雌二醇组(E2组),每组15只,分别研究雌激素在大鼠部分肝缺血再灌注损伤中的作用,以血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(AKP)水平作为评定肝损伤的指标.结果:F组的ALT、AST、AKP水平明显低于M组及O组(P＜0.05);E2组的ALT、AST、AKP水平明显低于M组及O组(P＜0.05).结论:雌激素对大鼠部分肝缺血再灌注损伤具有明显的保护作用.
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| 关 键 词： | 部分肝 缺血再灌注 雌激素 |
| 文章编号： | 1004-6879（2006）03-0229-03 |
| 收稿时间： | 2006-03-18 |
| 修稿时间： | 2006-03-18 |
EFFECTS OF ESTROGEN ON REDUCED-SIZE LIVER ISCHEMIA REPERFUSION INJURY IN RATS |
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| YAN Feng-xia , LIU Yan-hua,WANG Yan-hui , et al. EFFECTS OF ESTROGEN ON REDUCED-SIZE LIVER ISCHEMIA REPERFUSION INJURY IN RATS[J]. Journal of Chengde Medical College, 2006, 23(3): 229-231 |
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| Authors: | YAN Feng-xia LIU Yan-hua WANG Yan-hui et al |
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| Affiliation: | Chengde Medical College, Hebei Chengde 067000, China |
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| Abstract: | Objective: To study the effects of estrogen on reduced-size liver ischemia reperfusion injury in rats. Methods: 60 SD rats were divided into female group (F group) , male group (M group) , ovariectomy group (O group) and estrogen group (E2 group) at random. All the rats were made reduced-size liver ischemia reperfusion rats model, and ALT, AST, AKP content in serum were applied to evaluate the hepatic function in ischemia reperfusion injury. Results: The ALT, AST, AKP content in serum of F group were obviously lower than that of M group and O group (P<0. 05). The ALT, AST, AKP content in serum of E2 group were obviously lower than that of. M group and O group (P<0. 05). Conclusions: Es- trogen has significant protection for liver in reduced-size liver ischemia reperfusion injury. |
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| Keywords: | Reduced-size liver Ischemia reperfusion Estrogen |
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