抑郁情绪对冠心病患者 CRP及低密度脂蛋白水平的影响

目的：探讨抑郁情绪对冠心病患者血清炎症因子C-反应蛋白（CRP）和低密度脂蛋白水平（LDL）的影响。方法选取本院接诊的有、无抑郁情绪的冠心病门诊或住院患者各40例；选取同期在本院体检的无冠心病的健康体检者20例为对照组。测量比较三组血清CRP、LDL水平，并分析抑郁量表评分与CRP、LDL的相关性。结果抑郁冠心病患者抑郁自评量表（SDS）（46.22±3.90）分]、汉密尔顿抑郁量表（HAMD）（24.39±3.08）分]评分均明显高于对照组（22.46±6.22）分、（10.36±4.22）分]及非抑郁冠心病组患者（29.36±5.34）分、（10.30±4.11）分]（ P ＜0.05），而对照组和非抑郁冠心病组间SDS、HAMD量表评分差异无统计学意义（ P ＞0.05）；抑郁冠心病患者CRP（24.36±3.25）mg/L]、LDL（2.85±1.42） mmol/L]水平均明显高于对照组及非抑郁冠心病组患者（ P ＜0.05），非抑郁冠心病患者的CRP、LDL水平明显高于对照组（ P＜0.05）；SDS、HAMD量表评分与CRP、LDL、心率呈正相关（ P ＜0.05）。结论冠心病患者保持轻松乐观的心态，对于改善冠心病的治疗效果具有促进作用。

Effects of depression on C-reactive protein and low-density lipoprotein levels in patients with coronary artery disease

Objective To investigate effects of depression on C-reactive protein （ CRP） and low density lipoprotein （ LDL） levels in patients with coronary artery disease .Methods Eighty coronary heart disease patients with and without depression and 20 coronary heart disease-free cases were selected , CRP and LDL levels were measured and compared among three groups .The correlation of depression scores with CRP and LDL were analyzed .Results Depression self rating scale （ SDS） , and Hamilton Depression Scale （ HAMD） scores of patients with coronary heart disease （ CHD）＋depression were 46.22 ±3.90 , and 24.39 ±3.08 ,which were sig-nificantly higher than control group （22.46 ±6.22,10.36 ±4.22） and non-depressed CHD patients （29.36 ±5.34, and 10.30 ± 4.11 ） （ P 〈0.05 ） , respectively .There were no significant difference between control group and non-depressed CHD patients for SDS and HAMD scores （ P 〉0.05 ） .CRP and LDL levels of patients with CHD ＋depression were （ 24.36 ±3.25 ） mg/L, （ 2.85 ± 1.42 ） mmol/L, which were significantly higher than control group and non-depressed CHD patients （ P 〈0.05 ） .CRP and LDL lev-els of non-depressed CHD patients were higher than control group （ P 〈0.05 ） .SDS, and HAMD scores had a positive correlation with CRP, LDL, and heart rate （ P 〈0.05）.Conclusions CHD patients should remain optimistic relaxed state of mind to improve the treatment of coronary heart disease .