咪达唑仑联合丙泊酚对纤支镜受检尘肺病患者血压的影响

目的观察经鼻纤支镜气管检查治疗中患者使用咪达唑仑、丙泊酚等镇静麻醉效果,探讨经鼻纤支镜气管检查治疗中使用镇静麻醉药物后对血压的影响。方法将200例择期需经鼻纤支镜气管检查治疗的尘肺病人,随机分为A、B两组,A组仅术前均予2%利多卡因和1%丁卡因注射液局部浸润麻醉,B组术前均予2%利多卡因和1%丁卡因注射液局部浸润麻醉后应用咪达唑仑联合丙泊酚进行镇静麻醉。结果 A组各年龄段患者术后收缩压升高明显高于B组(P均<0.01);A组术中术后收缩压升高率为56.00%;B组术中术后收缩压升高率为16.00%,差异有统计学意义(χ2=17.361,P<0.001)。结论咪达唑仑联合丙泊酚麻醉效果良好,对患者血压升高有明显改善,减少患者的紧张情绪,方便患者配合术者操作,明显减少患者痛苦和并发症,简单易行,可广泛应用于临床。

Effect of midazolam combined with propofol on blood pressure in patients with pneumoconiosis undergoing fiberoptic bronchoscopy

Objective To observe the sedative and anesthetic potency of midazolam and propofol anesthe- sia for tracheal examination using nasal fiberoptic bronchoscope and for treatment of patients with pneumoconiosis, and to explore the effect of sedative drugs on blood pressure during fiberoptic bronchoscopy anesthesia. Methods A total of 200 patients with pneumoconiosis undergoing elective nasal fiberoptic bronchoscopy for tracheal examination and treatment of pneumoconiosis were randomly divided into two groups. Group A were given 2 % lidocaine and 1% tetracaine injection for local infiltration anesthesia alone preoperatively. All patients in group B were treated with 2 % lidocaine and 1% bupivacaine injection of local infiltration anesthesia as well as with midazolam combined with propofol for sedation anesthesia preoperatively. Results The systolic blood pressure （SBP） elevation in group A （all ages subgroup） was significantly higher postoperative than group B （all ages subgroup） （all P 〈0.01）. The intraoperative and postoperative elevated SBP incidence rate in group A was 56.00% ; and the intraoperative and postoperative elevated SBP incidence rate in group B was 16.00%, there was statistically significant difference （Х^2= 17. 361, P〈0. 001）. Conclusion Midazolam combined with propofol anesthesia can have better results, which can significantly improve patients＇ elevated blood pres- sure, reduce the tension of patients, is convenient for patients compliance with operation, significantly reduce the patients pain and the complications. It is an easy and simple anesthetic method and can be widely used in clinical.