| 羧乙基锗倍半氧化物对实验诱发小鼠前胃癌变过程中的免疫作用 |
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| 引用本文： | 卢朝晖,和瑞芝,千高峰,原志庆,千新来,任金萍,冯艳玲,王凤荣. 羧乙基锗倍半氧化物对实验诱发小鼠前胃癌变过程中的免疫作用[J]. 肿瘤基础与临床, 1994, 0(4) |
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| 作者姓名： | 卢朝晖 和瑞芝 千高峰 原志庆 千新来 任金萍 冯艳玲 王凤荣 |
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| 作者单位： | 新乡医学院病理学教研室，河北医学院基础医学研究所 |
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| 摘 要： | Ｎ—亚硝基肌氨酸乙酯（ＮＳＥＥ）诱发昆明小鼠前胃癌变，再以羧乙基锗倍半氧化物（Ｇｅ－１３２）治疗结果发现实验组中癌细胞的浸润深度显著浅于对照组（Ｐ＜０．０５）；实验组核仁组成区相关嗜银蛋白（ＡｇＮＯＲ）计数及细小、不规则颗粒所占比例均低于对照组（Ｐ＜０．０５）；实验组癌周淋巴细胞浸润反应则较对照组显著（Ｐ＜０．０５）。提示Ｇｅ－１３２对ＮＳＥＥ诱发的小鼠前胃癌有一定的治疗作用；并从免疫形态学证实介导宿主免疫反应可能是Ｇｅ－１３２发挥抗癌作用的机制之一。本研究为Ｇｅ－１３２用于临床提供理论依据。
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| 关 键 词： | 羧乙基锗倍半氧化物，亚硝胺前体物，前胃癌，核仁组成区，小鼠 |
Immune Activity of Carboxyethylgermanium Sesquioxide in Carcinogenesis of Mouse Forestomach |
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| Lu Zhaohui, et al. Immune Activity of Carboxyethylgermanium Sesquioxide in Carcinogenesis of Mouse Forestomach[J]. journal of basic and clinical oncology, 1994, 0(4) |
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| Authors: | Lu Zhaohui et al |
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| Abstract: | In this study, cancer in mouse forestomach induced by N-nitrososarcosine ethylester (NSEE) was treated with carboxyethylgermanium sesquioxide (Ge-132). The result showed that the infiltration depth of cancer cells in the therapeutic group was remarkably less than that in the control group; The therapeutic group contained less argyrophilic nucleolar organizer regions (Ag-NOR) thanthe control group,and tiny,irregular Ag-NOR were more frequently seen in the control group; Lymphocyte infiltratting response in the therapeutic group was more serious than that in the controls. It suggested that Ge-132 was effective on the treatment of cancer in mouse forestomach,and morphological study showed that increasing immunity may be one of the mechanisms for the antitumor activity of Ge-132. This study provided an experimental basis for the application of Ge-132 to clinic. |
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| Keywords: | carboxyethylgermanium sesquioxide cancer in forestomachp N-nitrososarcosine ethlester nucleolar organizer regions mouse |
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