Comparison of chemotherapy regimens for concurrent chemoradiotherapy in unresectable stage III non-small cell lung cancer |
| |
| Authors: | Hideyuki Harada Nobuyuki Yamamoto Toshiaki Takahashi Masahiro Endo Haruyasu Murakami Asuka Tsuya Yukiko Nakamura Akira Ono Satoshi Igawa Takehito Shukuya Akihiro Tamiya Tetsuo Nishimura |
| |
| Affiliation: | 1. Division of Radiation Oncology, Shizuoka Cancer Center, Sunto, Shizuoka, Japan
2. Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto, Shizuoka, 411-8777, Japan
|
| |
| Abstract: | Background The purpose of this study was to retrospectively compare the survival and toxicities associated with chemoradiotherapy using full-dose and weekly regimens in patients with stage III non-small cell lung cancer. Methods Consecutive patients who received concurrent chemoradiotherapy between October 2002 and June 2006 at our institution were enrolled. The prescribed dose for thoracic radiotherapy was 60 Gy in 30 fractions for all the patients. Results Fifty-nine patients were enrolled; 36% of the patients were treated with full-dose regimens and 64% with weekly regimens. The patient characteristics were similar in the two groups. In both univariate and multivariate analyses, treatment with weekly regimens was associated with a better overall survival than that with full-dose regimens (2-year survival rates: 75% for weekly regimens vs 41% for full-dose regimens). The toxicities and compliance in the two groups were comparable. Conclusion Weekly regimens exhibited more favorable overall survival as compared to full-dose regimens in this retrospective study. Confirmation of the results by a randomized phase III trial is warranted. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
