Modulatory effect of carnosine and related compounds on the oxidative burst in barium sulfate-activated leukocytes |
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| Authors: | O V Tyulina V E Kagan A A Boldyrev |
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| Institution: | (1) M. V. Lomonosov State University, Moscow;(2) Pittsburgh University, Philadelphia |
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| Abstract: | The effect of carnosine and its natural derivatives on the generation of reactive oxygen species by leukocytes and on the
myeloperoxidase reaction was studied. The chemiluminescence of samples in the course of cell activation was measured in the
presence of luminol or lucigenin. Carnosine was found to produce a two-way effect, i.e., neutralization of singlet oxygen
and hypochlorite anion simultaneously with activation of the system of superoxide-anion generation.
Translated fromByulleten Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
11, pp. 463–465, November, 1994
Presented by I. P. Ashmarin, Member of the Russian Academy of Medical Sciences |
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| Keywords: | carnosine and related compounds leukocyte oxidative burst myeloperoxidase |
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