血栓弹力图在急性脑梗死患者溶栓前后的差异性研究

目的探讨血栓弹力图(thrombelastograph,TEG)指标在急性脑梗死溶栓治疗前、后及与正常健康者之间的差异。方法选取我院经重组人组织型纤溶酶原激活剂静脉溶栓治疗的急性脑梗死52例(脑梗死组)及体检健康者36例(对照组),分别进行TEG检测并对其参数进行比较。结果脑梗死组溶栓前凝血反应时间(R)、血细胞凝集块形成时间(K)均小于对照组,血细胞凝集块形成速率(α角)、最大血块强度(MA)均大于对照组,差异均有统计学意义(P均0.01);溶栓治疗后,R值、K值延长,MA值、α角减小,与溶栓前比较差异均有统计学意义(P均0.01);脑梗死组溶栓后各指标与对照组比较差异无统计学意义(P0.05)。结论 TEG指标可及时准确地评估急性脑梗死患者的凝血状态,可作为评价溶栓治疗效果的指标之一。

The Difference of Thrombelastogram in Patients with Cerebral Infarction before and after the Treatment of Intravenous Thrombolysis

Objective To explore the difference of thrombelastogram （TEG） between patients with cerebral infarction be- fore and after the treatment of intravenous thrombolysis with healthy people. Methods A total of 52 patients （ group A） with cere- bral infarction treated with intravenous thrombolysis of human tissue-type plasminogen activator and 36 healthy control （group B） were recruited in this study. The TEG test was respectively conducted in the two groups, and the indexes were compared. Results In group A, values of reaction time （R） of blood coagulation before thrombolysis and formative time of hemagglutination （K） were significantly lower than those in group B, while values of formative speed of hemagglutination （alpha angle） and maximum magni- tude （MA） of cruor were significantly higher than those of group B （P 〈 0.01 ） ; after thrombolysis treatment, values of R and K in- creased, and MA value and alpha angle decreased, and the differences showed statistically significances （P 〈 0.01 ） ; there were no statistical siguificances in indexes after thrombolysis treatment in group A and B （ P 〉 0.05 ）. Conclusion TEG parameter may quickly and accurately evaluate the blood coagulation state of patients with acute cerebral infarction, so it can be used as one of in- dexes of evaluating the effect of thrombolysis treatment.