补肾健脾活血方对去卵巢大鼠松质骨超微结构的影响

目的：观察补肾健脾活血方对去卵巢大鼠股骨下段松质骨超微结构的影响。方法：84只雌性大鼠随机分成正常组、假手术组、模型组、中药对照组、西药对照组、补肾健脾活血方大、小剂量组共7组。采用卵巢切除的方法进行动物造模，灌胃治疗90天后取股骨下段松质骨进行电镜观察。结果：补肾健脾活血方能明显改善骨胶原的排列，减少断裂的骨胶原，且大剂量组的作用明显优越于中药对照组、西药对照组和小剂量组。结论：补肾健脾活血方能减少骨吸收促进骨形成，改善松质骨的超微结构，从而具有增加骨强度的作用。

Effect of Bushen Jianpi Huoxue Recipe on Chancellors Bone Ultramicrostructure of Ovariectomiced Rats

Objective:To observe the effect of Bushen Jianpi Huoxue recipe on chancellors bone ultrastructure of ovariectomiced rats.Methods:84 female rats were divided to 7 groups:normal group, sham operation group, model group, chinese herb contrast group, west drug contrast group, large dose group of Bushen Jianpi Huoxue recipe(large dose group)and small dose group of Bushen Jianpi Huxue recipe(small dose group). To make rat postmenopausal osteoporasis model by ablating ovary. After 90 days of treatment to observe chancellors bone of femur with electron microscope.Results:Bushe Jianpi Huoxue recipe can improve sequonse of bone collagen and decrease dirupted bone collage obviously. The effect of large dose group is superior to Chinese herb contrast group, west drug contrast group and small dose group.Conclusion:Bushen Jianpi Huoxue recipe can decrease bone absorption, enhence bone formation and improve ultrastructure of chancellors bone. Bushen Jianpi Huoxue recipe can increase bone strength.