| 核酸适体技术研究进展 |
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| 引用本文： | 王成刚,莫志宏.核酸适体技术研究进展[J].生物医学工程学杂志,2006,23(2):463-466. |
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| 作者姓名： | 王成刚 莫志宏 |
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| 作者单位： | 1. 重庆大学,生物工程学院,重庆,400044
2. 重庆大学,化学化工学院,重庆,400044 |
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| 摘 要： | 核酸适体（aptamer）指的是经体外筛选技术SELEX（指数富集配体系统进化）筛选出的能特异结合蛋白质或其他小分子物质的寡聚核苷酸片段，对可结合的配体有严格的识别能力和高度的亲和力。核酸适体在生物传感器、新药开发以及纳米技术等方面有着广泛的用途，本文对核酸适体近两年的研究进展进行综述。
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| 关 键 词： | 核酸适体 指数富集配体系统进化 生物传感器 新药开发 纳米技术 |
| 收稿时间： | 2004-11-26 |
| 修稿时间： | 2004-11-262005-01-14 |
Current Reviews in Aptamers |
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| Wang Chenggang,Mo Zhihong.Current Reviews in Aptamers[J].Journal of Biomedical Engineering,2006,23(2):463-466. |
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| Authors: | Wang Chenggang Mo Zhihong |
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| Institution: | 1. College of Bioengineering, Chongqing University, Chongqing 400044, China; 2. College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, China |
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| Abstract: | Aptamers are oligo-nucleotides which are selected by SELEX(systematic evolution of ligands by exponential enrichment) in vitro,it can bind protein or other small molecules with high specificity and affinity.Researches on aptamers have achieved much progress in biosensor,drug development and nano technology.This article has reviewed the researches and applications of aptamers in the past two years. |
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| Keywords: | Aptamer Systematic evolution of ligands by exponential enrichment(SELEX) BiosensorDrug development Nano technology |
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