Impact of protease inhibitors on intrahepatic hepatitis C virus viral load |
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Authors: | Neau D Trimoulet P Winnock M Le Bail B Schvoerer E Legrand E Ragnaud J M Dupon M Fleury H Lafon M E |
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Institution: | Laboratoire de Virologie Systématique et Moléculaire, Centre Hospitalo-Universitaire Pellegrin, Bordeaux, France. |
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Abstract: | During chronic hepatitis C, hepatitis C virus (HCV) load in plasma was shown to be higher in HIV-co-infected than in immunocompetent patients 1]. The reason for this increased HCV replication is not known. It may be as a result of HIV-induced immune deficiency 2], although some authors did not find any correlation with the CD4 cell count 3]. A direct interaction between HCV and HIV was also hypothesized 4]. Protease inhibitors (PI) used in highly active antiretroviral therapy (HAART) have no HCV reduction effect during the first months of treatment 5-8]. However, a decrease in HCV plasma load was recently described in patients treated with HAART for a year 9,10]. We therefore investigated the potential impact of HAART on intrahepatic HCV load. |
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