Changes in articular cartilage and subchondral bone after intra-articular osteotomies of the distal femur fixed with biodegradable thread: Histomorphometric study in rabbits |
| |
| Affiliation: | 1. Chemical Engineering Department, Universidad de Los Andes, Colombia;2. Chemical Engineering Department, University of Waterloo, Canada;1. Universidad de Concepción, Facultad de Ciencias Químicas, Edmundo Larenas 129, Casilla, 160C, Chile;2. National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, 12120, Thailand;3. Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007, Tarragona, Spain;4. Catalysis Engineering, Department of Chemical Engineering, Delft University of Technology, Van der Maasweg 9, 2629 HZ, Delft, the Netherlands;5. Institute of Catalysis and Petrochemistry (CSIC), Cantoblanco, 28049, Madrid, Spain;1. Departamento de Ingeniería Química y Bioprocesos, Pontificia Universidad Católica de Chile, Avenida Vicuña Mackenna 4860, Macul, Santiago, Chile;2. Millenium Nuclei on Catalytic Processes Toward Sustainable Chemistry (CSC), Chile;3. Instituto de Ciencias Químicas Aplicadas, Theoretical and Computational Chemistry Center, Facultad de Ingeniería, Universidad Autónoma de Chile, Av. Pedro de Valdivia 425, Santiago, Chile;4. Instituto de Catálisis y Petroleoquímica CSIC, Marie Curie 2, 28049, Madrid, Spain;5. Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Avenida Vicuña Mackenna 4860, Macul, Santiago, Chile;6. Unidad de Desarrollo Tecnológico, Universidad de Concepción, Coronel, Chile |
| |
| Abstract: | The quantitative, histomorphometric changes of the articular cartilage and subchondral bone of 117 rabbit's right knees were measured after intra-articular osteotomies of the distal femur and the medial condyle of femur fixed with n-butyl-2-cyanoacrylate, bone cement and polyglycolic acid thread or with polyglycolic acid thread alone. The left knees served as controls. The numerical values were compared statistically with Student's t-test. Follow-up periods were 1, 3, 6, 12, 24 and 48 weeks. There was no significant difference between the fixation methods used. A remarkable increase (P < 0·001) of the amount of articular cartilage and decrease (P < 0·002) of the amount of subchondral bone was noticed in the medial condyle of the operated knees. In the lateral condyle the corresponding changes of the cartilage (P < 0·1) and of the bone (P < 0·1) were not as prominent. The increase of the amount of the medial condyle cartilage was larger after the medial condyle osteotomies than after the distal femoral osteotomies. If the healing of the osteotomies was disturbed then the increase of the cartilage was larger than after normal bone healing. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
