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Direct molecular evidence for both multicentric and monoclonal carcinogenesis followed by transdifferentiation from hepatocellular carcinoma to cholangiocarcinoma in a case of metachronous liver cancer |
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| Authors: | Sumie Ohni Hiromi Yamaguchi Yukari Hirotani Yoko Nakanishi Yutaka Midorikawa Masahiko Sugitani Hiromu Naruse Tomohiro Nakayama Makoto Makishima Mariko Esumi |
| Institution: | 1.Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo 173-8610, Japan;2.Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo 173-8610, Japan;3.Department of Surgery, Nihon University School of Medicine, Tokyo 173-8610, Japan |
| Abstract: | |
| Keywords: | metachronous cancer cancer evolution intrahepatic metastasis multicentric carcinogenesis hepatocellular carcinoma combined hepatocellular-cholangiocarcinoma transdifferentiation laser capture microdissection next-generation sequencing |