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MLL insertion with MLL-MLLT3 gene fusion in acute leukemia: case report and review of the literature |
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| Authors: | Soler Gwendoline Radford Isabelle Meyer Claus Marschalek Rolf Brouzes Chantal Ghez David Romana Serge Berger Roland |
| Institution: | aService de cytogénétique, Assistance PubliqueeHôpitaux de Paris (APHP), Centre Hospitalier Universitaire (CHU) Necker-Enfants Malades, 149 rue de Sèvres, 75743, paris Cedex 15, France bInstitut National de la Santé et de la Recherche Scientifique (INSERM), EMI0210, 149 rue de Sèvres, 75743, Paris Cedex 15, France cInstitute of Pharmaceutical Biology/DCAL/ZAFES/CEF, JWG-University Frankfurt, Biocenter, Max-von Laue-Str. 9, Frankfurt/Main, D-60438, Germany dLaboratoire d'Hematologie Biologique, APHP, CHU Necker-Enfants Malades, 149 rue de Sèvres, 75743 Paris Cedex 15, France eService d'Hématologie, APHP, CHU Necker-Enfants Malades, 149 rue de Sèvres, 75743 Paris Cedex 15, France |
| Abstract: | A new chromosomal insertion involving the MLL gene was detected by fluorescence in situ hybridization in a patient with acute myeloblastic leukemia (AML) and a t(9;11)(p21;q13). Genomic polymerase chain reaction confirmed the MLL-MLLT3 gene fusion. A review of the literature on MLL insertions shows that the opposite orientation of the genes involved in the fusion plays a role in the genesis of the rearrangement in most of the cases reported. |
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