| 灭螺药物氯代水杨胺急性毒性试验 |
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| 引用本文： | 元艺,徐兴建,魏凤华,李桂玲,赵云斌,刘敏. 灭螺药物氯代水杨胺急性毒性试验[J]. 中国血吸虫病防治杂志, 2007, 19(3): 188-191 |
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| 作者姓名： | 元艺 徐兴建 魏凤华 李桂玲 赵云斌 刘敏 |
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| 作者单位： | 1. 湖北省疾病预防控制中心血吸虫病防治研究所,武,汉,430079
2. 华中科技大学同济医学院 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 目的评价新型灭螺药氯代水杨胺(LDS)的急性毒性。方法按照《农业登记毒理学试验方法》GB 15670-1995,将LDS分别进行大鼠急性经口、经皮、吸入毒性试验,家兔急性眼刺激和皮肤刺激试验,以及豚鼠皮肤致敏试验。结果依据分级评价标准,LDS对大鼠急性经口、经皮、吸入毒性属微毒级,对家兔属无急性眼刺激性及无急性皮肤刺激性,对豚鼠皮肤致敏属弱致敏类。结论 LDS对哺乳动物的毒性属微毒级,是一种新型的安全灭螺药。
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| 关 键 词： | 灭螺药 氯代水杨胺 急性毒性试验 |
| 文章编号： | 1005-6661（2007）03-0188-04 |
| 修稿时间： | 2007-01-15 |
Acute toxicity of LDS, a molluscicide |
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| Yuan Yi,Xu Xing-jian,Wei Feng-hua,Li Gui-ling,Zhao Yun-bin,Liu Min. Acute toxicity of LDS, a molluscicide[J]. Chinese journal of schistosomiasis control, 2007, 19(3): 188-191 |
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| Authors: | Yuan Yi Xu Xing-jian Wei Feng-hua Li Gui-ling Zhao Yun-bin Liu Min |
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| Affiliation: | 1 Institute of Schistosomiasis Control, Hubei Center for Disease Control and Prevention, Wuhan 430079, China; 2 Tongji Medical College, Huazhong University of Science and Technology, China |
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| Abstract: | Objective To investigate the acute toxicity of LDS, a molluscicide. Methods Ac-cording to "the method of toxicity test for agriculture register" GB15670- 1995, an acute toxicitytest was carried out via mouth, skin and inbreathe with Wistar rat. Meanwhile, the eye and skinstimulating test with rabbit as well as skin stimulating test with guinea pig were also conducted.Results Based on the classification of appraising criterion on acute toxicity test via mouth, skin andinbreathe with Wistar rat, LDS belonged to a feebleness toxicity degree. Based on intension classifi-cation criterion of acute skin stimulation, LDS was of no acute skin stimulation to the rabbit. Basedon intension classification criterion of acute eye stimulation, LDS was of no acute eye stimulation tothe rabbit. Based on intension classification criterion of impressible rate, LDS was feebly impress-ible. Conclusion LDS has a feeble toxicity degree to mammal. |
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| Keywords: | Molluscicide LDS Acute toxicity test |
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