Effects of chronic treatment with methadone and naltrexone on sleep in addicts |
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Authors: | J. Staedt F. Wassmuth G. Stoppe G. Hajak A. Rodenbeck W. Poser E. Rüther |
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Affiliation: | (1) Department of Psychiatry, Georg August University, D-37075 Göttingen, Germany |
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Abstract: | Previous studies have described sleep disturbance secondary to chronic opiate use and abuse. Drug-dependency insomnia is of interest because chronic sleep disturbances can promote depressive symptoms which could lead to a drug relapse. For the first time we compared the polysomnographic parameters of 10 methadone-substituted outpatients and 10 naltrexone-treated outpatients. Methadone (-opioid agonist) produced a marked fragmentation of the sleep architecture with frequent awakenings and a decrease in EEG arousals. In comparison with methadone and controls, the naltrexone (-opioid antagonist) group showed the shortest sleep latency and the longest total sleep time. These data indicate that -agonists and -antagonists have different effects on sleep. The implications, especially the involvement of opioid-dopamine interactions on sleep and movements during sleep, are discussed. |
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Keywords: | Sleep disturbance Methadone Naltrexone Opioid-dopamine interaction |
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