Effect of tobacco-leaf extract administration on liver,lung, intestine,and serum enzymes

Tobacco-leaf extract induced benzpyrene hydroxylase activities of liver and lung of male albino rats after 7, 30, and 62 days of oral administration. Aniline hydroxylase activity of liver and lung showed an increase after 30 days of administration, while the N-demethylase activity of liver showed a small increase at the first phase and a decrease after 62 days. Of the lysosomal enzymes investigated, β-glucuronidase activity of both liver and lung showed a significant increase. Increased activities of hepatic lysosomal acid phosphatase was observed at 7 and 30 days of leaf-extract administration. A decrease was observed in sucrase and maltase activities of intestinal brush border after 7 and 30 days of tobacco-leaf extract administration. No significant change in serum enzymes was observed under the conditions of the present study.