慢性胃炎病理组织学表现与幽门螺杆菌的关系

目的：以大样本方式进一步了解幽门螺杆菌（Ｈｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉ，Ｈｐ）与慢性胃炎的关系。方法：回顾性分析连续１２个月内在我院被胃镜诊断为慢性胃炎的胃窦粘膜病理组织学检查结果。结果：共１６５８例，其中Ｈｐ阴性８８９例，Ｈｐ阳性７６９例。在Ｈｐ阴性病人中轻度慢性炎症（４２．７％）比重度（２２．１％）多见；在Ｈｐ阳性病人中轻度慢性炎症（７．５％）比重度（７３．２％）少见；随Ｈｐ菌量的增加，重度炎症明显增加，轻度炎症明显减少；肠化生和粘膜萎缩在Ｈｐ阳性病人中多见，分别为２０．２％和１０．３％（其在Ｈｐ阴性病例分别为１４．５％和７．５％）。结论：Ｈｐ是慢性胃炎的重要致病因素，它与胃窦粘膜慢性炎症程度及肠化生和粘膜萎缩有密切的关系

Relationship between pathohistologic presentation of antral mucosaand Helicobacter pylori in chronic gastritis

Objective: To evaluate further relationship between Helicobacter pylori (Hp) and chronic gastritis by the way of big samples. Methods: Analyse retrospectively pathohistologic results of antral mucosa in chronic gastritis patients that were diagnosed by gastroscopy in our hospital for 12 months. Results: (1) There were 1 658 cases, Hp negative 889 and Hp positive 769. (2) The cases with mild chronic inflammation (42.7%) were more than those with severe one (22.1%) in Hp negative patients; the cases with mild chronic inflammation(7.5%) were much fewer than that with severe one (73.2%) in Hp positive patients. (3) Chronic inflammatory degree increased gradually with increasing density of Hp. (4) Intestinal metaplasia and atrophic lesions distributed mostly in Hp positive patients, 20.2% and 10.3%, respectively(14.5% and 7.5% respectively in Hp negative patients). Conclusion: (1) Hp is a very important pathogenic factor in chronic gastritis. (2) Hp is associated with not only degree of chronic inflammation but also intestinal metaplasia and atrophic lesion of antral mucosa in chronic gastritis.