中药五味药性理论辨识及其化学生物学实质表征路径

从中药五味概念、五味与四气、归经、升降沉浮、功效的关系以及临证配伍等方面对传统中药五味理论进行系统梳理和辨识。以仿生模型为基础,结合化学分析手段、受体理论、生物效应评价模型、药动学方法等对五味、功效、四气、归经、升降浮沉等中药性味研究,提出现代化学生物学表征路径。最后,从系统论和还原论的角度探讨了五味药性研究的思路方法。

Identification of Chinese materia medica and its chemical biology characterization path on five taste theory

Theory on five tastes of Chinese materia medica is systematically analyzed and identified in the concept on five tastes and correlation between five tastes and four properties, channel tropism, ascending, and descending, floating and sinking, function and clinical compatibility. In this paper, based-bionic model was combining with chemical analysis tools, receptor theory, biological responses, model evaluation, and pharmacokinetic methods to study five tastes and four properties, meridian and functions, and to propose modernization of chemical-biological characterization pathway. Finally, authors explore the idea and method research on medicine taste and property according to systems theory and reductionist.