| 芥子中芥子碱类和硫代葡萄糖苷类成分化学稳定性和质量评价研究进展 |
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| 引用本文： | 张青山,王卓,孔铭,刘丽芳,李松林.芥子中芥子碱类和硫代葡萄糖苷类成分化学稳定性和质量评价研究进展[J].中草药,2015,46(1):148-156. |
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| 作者姓名： | 张青山 王卓 孔铭 刘丽芳 李松林 |
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| 作者单位： | 南京中医药大学附属中西医结合医院 中药质量研究室, 江苏 南京 210028;中国药科大学 天然药物活性组分与药效国家重点实验室, 江苏 南京 210009;南京中医药大学附属中西医结合医院 中药质量研究室, 江苏 南京 210028;中国药科大学 天然药物活性组分与药效国家重点实验室, 江苏 南京 210009;南京中医药大学附属中西医结合医院 中药质量研究室, 江苏 南京 210028;江苏省中医药研究院和中国中医科学院江苏分院 中药代谢组研究室, 江苏 南京 210028;中国药科大学 天然药物活性组分与药效国家重点实验室, 江苏 南京 210009;南京中医药大学附属中西医结合医院 中药质量研究室, 江苏 南京 210028;江苏省中医药研究院和中国中医科学院江苏分院 中药代谢组研究室, 江苏 南京 210028 |
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| 基金项目： | 国家高技术研究发展计划资助项目("863"计划)(2014AA022204) |
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| 摘 要： | 芥子中主要化学成分为硫代葡萄糖苷类和芥子碱类。芥子碱类成分具有抗氧化、抗雄性激素、缓慢降压等多种药理活性;硫代葡萄糖苷类成分及其降解产物具镇咳平喘、抗氧化、抗癌、抗菌等功效。综述了芥子中硫代葡萄糖苷类和芥子碱类成分的化学组成、稳定性和质量控制方法的最新研究进展,以期对芥子药材及其相关产品的质量控制和合理开发利用提供科学指导。
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| 关 键 词： | 芥子 硫代葡萄糖苷类 芥子碱类 稳定性 质量评价 |
| 收稿时间： | 2014/8/14 0:00:00 |
Advances in study on chemical components, stability, and quality evaluation of sinapinoids and glucosinolates in Sinapis Semen |
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| ZHANG Qing-shan,WANG Zhuo,KONG Ming,LIU Li-fang and LI Song-lin.Advances in study on chemical components, stability, and quality evaluation of sinapinoids and glucosinolates in Sinapis Semen[J].Chinese Traditional and Herbal Drugs,2015,46(1):148-156. |
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| Authors: | ZHANG Qing-shan WANG Zhuo KONG Ming LIU Li-fang and LI Song-lin |
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| Institution: | Department of Pharmaceutical Analysis, Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210028, China;The State Key Laboratory of Natural Medicines Components and Pharmcodynamics, China Pharmaceutical University, Nanjing 210009, China;Department of Pharmaceutical Analysis, Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210028, China;The State Key Laboratory of Natural Medicines Components and Pharmcodynamics, China Pharmaceutical University, Nanjing 210009, China;Department of Pharmaceutical Analysis, Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210028, China;Department of Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine and Jiangsu Branch of China Academy of Chinese Medical Sciences, Nanjing 210028, China;The State Key Laboratory of Natural Medicines Components and Pharmcodynamics, China Pharmaceutical University, Nanjing 210009, China;Department of Pharmaceutical Analysis, Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210028, China;Department of Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine and Jiangsu Branch of China Academy of Chinese Medical Sciences, Nanjing 210028, China |
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| Abstract: | Sinapinoids and glucosinolates are the main chemical components in Sinapis Semen. Sinapinoids have significant biological activities, such as anti-oxidant, anti-androgen, lowering the blood pressure, and so on. Glucosinolates and their degradation products are known for its biological functions such as fungicidal, bactericidal, and in the treatment of cancer and cough. The latest progress on the chemical components, stability, and quality evaluation of sinapinoids and glucosinolates in Sinapis Semen is reviewed, which could provide some scientific guidance for the quality control and exploration of Sinapis Semen and its related products. |
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| Keywords: | Sinapis Semen glucosinolates sinapinoids stability quality evaluation |
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