Possible polyclonal B cell activation in mucocutaneous lymph node syndrome |
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Authors: | F. Furukawa G. Ohshio Y. Hamashima |
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Affiliation: | (1) Department of Dermatology, Faculty of Medicine, Kyoto University, Shogoin-Kawaracho, Sakyo-ku, 606 Kyoto, Japan;(2) Department of Pathology, Faculty of Medicine, Kyoto University, Shogoin-Kawaracho, Sakyo-ku, 606 Kyoto, Japan |
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Abstract: | Immunoserological studies on polyclonal B cell activation were carried out on 39 patients with mucocutaneous lymph node syndrome (MCLS) and in age-matched healthy individuals. The incidence of anti-mite, P. acnes (Kato) and EB virus antibodies, recently proposed as aetiological agents by some investigators, was increased in the patient group. Serum immunoglobulin (Ig) M level and IgM-anti-dinitrophenyl (DNP) antibodies, which are considered to be parameters of polyclonal B cell activation, were determined in MCLS cases. The level of serum IgM in MCLS was significantly elevated (0.02<P<0.05). Levels of anti-DNP antibodies in seven cases of MCLS (18%) were significantly higher than those of the controls (P<0.01). Nine of the ten pair sera in MCLS showed a stage-dependent decrease in anti-DNP antibodies. These results suggest that polyclonal B cell activation occurs in MCLS.Abbreviations MCLS mucocutaneous lymph node syndrome - P. acnes Propionibacterium acnes - EB virus Epstein-Barr virus - D. farinae Dermatophagoides farinae - PBS phosphatebuffered saline - Ig immunoglobulin - RT room temperature - FITC fluorescein isothiocyanate - DNP dinitrophenyl - BSA bovine serum albumin - OD optical density |
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Keywords: | Mucocutaneous lymph node syndrome Polyclonal B cell activation Anti-DNP antibodies |
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