| 促透剂对青藤碱凝胶经皮渗透作用的研究 |
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| 引用本文： | 张先洲,周健,何文,吴峰.促透剂对青藤碱凝胶经皮渗透作用的研究[J].中草药,2004,35(10):1115-1117. |
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| 作者姓名： | 张先洲 周健 何文 吴峰 |
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| 作者单位： | 1. 武汉大学人民医院,湖北,武汉,430060
2. 武汉市医学会,湖北,武汉,430014 |
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| 摘 要： | 目的 考察不同促透剂对青藤碱凝胶经皮渗透作用的影响。方法 采用改良Franz扩散池,以离体大鼠皮肤为透皮屏障,采用HPLC法测定青藤碱的经皮渗透量,分别考察含氮酮、薄荷脑、油酸的青藤碱凝胶的渗透情况。结果 几种促透剂对青藤碱凝胶透皮速率均有明显作用,其促渗强度依次为氮酮>薄荷脑>油酸,其中以2％氮酮和10％油酸混合物的促透作用最强。结论 2％氮酮和10％油酸混合物为青藤碱凝胶的最佳促透剂。
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| 关 键 词： | 青藤碱凝胶 经皮渗透 氮酮 薄荷脑 油酸 青藤碱 高效液相色谱 |
| 文章编号： | 0253-2670(2004)10-1115-03 |
| 收稿时间： | 2003/12/15 0:00:00 |
Penetration of transdermal enhancers on percutaneous permeation of Sinomenine Gels in vitro |
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| ZHANG Xian-zhou,ZHOU Jian,HE Wen and WU Feng.Penetration of transdermal enhancers on percutaneous permeation of Sinomenine Gels in vitro[J].Chinese Traditional and Herbal Drugs,2004,35(10):1115-1117. |
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| Authors: | ZHANG Xian-zhou ZHOU Jian HE Wen and WU Feng |
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| Institution: | Renmin Hospital of Wuhan University, Wuhan 430060, China;Renmin Hospital of Wuhan University, Wuhan 430060, China;Renmin Hospital of Wuhan University, Wuhan 430060, China;Wuhan Medical Association, Wuhan 430014, China |
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| Abstract: | Object To observe the effects of several transdermal enhancers on the permeation of sinomenine in Sinomenine Gels (SG). Methods The transdermal penetration in Franz diffusion cell for isolated rat skin of SG by different content enhancers with Azone, mentha camphor, and oleic acid, respetively was studied. The content of sinomenine was determined by HPLC. Results The above- mentioned transdermal enhancers showed the significant effect on sinomenine in SG in vitro with the density sequence as Azone>mentha camphor>oleic acid, and 2% Azone plus 10% oleic acid had the strongest effect in all. Conclusion 2% Azone plus 10% oleic acid as the enhancer of SG is the best. |
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| Keywords: | Sinomenine Gels (SG) percutaneous permeation Azone mentha camphor oleic acid sinomenine HPLC |
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