| E-(1-羟基-2,2-二甲基-6-苯亚甲基-3,3-亚乙二氧基环己基)乙酸的合成 |
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| 引用本文： | E-(1-羟基-2,2-二甲基-6-苯亚甲基-3,3-亚乙二氧基环己基)乙酸的合成[J]. 中国药科大学学报, 1992, (2): 71-73. |
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| 作者姓名： | 屠树滋 王德才 |
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| 摘 要： | 本文报道了化合物E-(1-羟基-2,2-二甲基-6-苯亚甲基-3,3-亚乙二氧基环己基)乙酸(12)的合成路线。并以2,2-二甲基-1,3-环己酮为起始原料,经过单缩酮化、羟醛缩合、Reformatsky反应,酯水解四步反应制得目的物,总收率为13.9%。
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| 关 键 词： | 美丽红豆杉素B 环己烷乙酸 单缩酮化 Reformatsky反应 |
Synthesis of E-(3,3-Ethylenedioxy-1-Hydroxy- 2,2-Dimethyl-6-Phenylmethylene) Cyclohexylacetic Acid |
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| Synthesis of E-(3,3-Ethylenedioxy-1-Hydroxy- 2,2-Dimethyl-6-Phenylmethylene) Cyclohexylacetic Acid[J]. Journal of China Pharmaceutical University, 1992, (2): 71-73. |
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| Abstract: | The route of synthesizing E-(3,3-ethylenedioxy-1-hydroxy-2,2-dimethyl-6-phenylmethylene) cyclohexy-laceticacid (12) was designed. This compound, which was obtained from 2, 2-dimethyl-1, 3-cyclohexanedione via monoketalization, condensation with benzaldehy |
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| Keywords: | Taxamairin B Cyclohexylacetic acid Monoketalization Reformatsky reaction |
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