|
|||||
|
|
MDSC subtypes and CD39 expression on CD8+ T cells predict the efficacy of anti-PD-1 immunotherapy in patients with advanced NSCLC |
|
| Authors: | Jiae Koh Youjin Kim Kyoung Young Lee Joon Young Hur Mi Soon Kim Boram Kim Hee Jin Cho Yeong Chan Lee Yeon Hee Bae Bo Mi Ku Jong-Mu Sun Se-Hoon Lee Jin Seok Ahn Keunchil Park Myung-Ju Ahn |
| Institution: | 1. Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea;2. Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Division of Hematology-Oncology, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea;3. Research Institute for Future Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea;4. Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea;5. Department of Digital Health, SAIHST, Sungkyunkwan University, Seoul, Korea;6. Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea |
| Abstract: | The major suppressive immune cells in tumor sites are myeloid derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), and Treg cells, and the major roles of these suppressive immune cells include hindering T-cell activities and supporting tumor progression and survival. In this study, we analyzed the pattern of circulating MDSC subtypes in patients with non-small cell lung cancer (NSCLC) whether those suppressive immune cells hinder T-cell activities leading to poor clinical outcomes. First, we verified PMN-MDSCs, monocytic-MDSCs (M-MDSCs), and Treg cells increased according to the stages of NSCLC, and MDSCs effectively suppressed T-cell activities and induced T-cell exhaustion. The analysis of NSCLC patients treated with anti-PD-1 immunotherapy demonstrated that low PMN-MDSCs, M-MDSCs, and CD39+CD8+ T cells as an individual and all together were associated with longer progression free survival and overall survival, suggesting PMN-MDSCs, M-MDSCs, and CD39+CD8+ T cells frequencies in peripheral blood might be useful as potential predictive and prognostic biomarkers. |
| Keywords: | CD39 IL-10 Immune checkpoint inhibitor MDSC Non-small cell lung cancer |