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Prevalence of atrial fibrillation dependent on coronary artery status: Insights from the LIFE-Heart Study |
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| Authors: | Jelena Kornej Sylvia Henger Timm Seewöster Andrej Teren Ralph Burkhardt Holger Thiele Joachim Thiery Markus Scholz |
| Institution: | 1. National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA;2. LIFE – Leipzig Research Center of Civilization Diseases, Leipzig University, Leipzig, Germany
Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, Germany;3. Department of Electrophysiology, Heart Center at University of Leipzig, Leipzig, Germany;4. LIFE – Leipzig Research Center of Civilization Diseases, Leipzig University, Leipzig, Germany;5. LIFE – Leipzig Research Center of Civilization Diseases, Leipzig University, Leipzig, Germany Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany;6. Department of Internal Medicine/Cardiology, Heart Center at University of Leipzig, Leipzig, Germany |
| Abstract: | BackgroundCoronary artery disease (CAD) is a significant risk factor for atrial fibrillation (AF). Experimental studies demonstrated that atrial ischemia induced by right coronary artery (RCA) stenosis promote AF triggers and development of electro‐anatomical substrate for AF.AimTo analyze the association between AF prevalence and coronary arteries status in the LIFE‐Heart Study.MethodsThis analysis included patients with available coronary catheterization data recruited between 2006 and 2014. Patients with acute myocardial infarction were excluded. CAD was defined as stenosis ≥75%, while coronary artery sclerosis (CAS) was defined as non‐critical plaque(s) <75%.ResultsIn total, 3.458 patients (median age 63?years, 34% women) were included into analysis. AF was diagnosed in 238 (6.7%) patients. There were 681 (19.7%) patients with CAS and 1.411 (40.8%) with CAD (27.5% with single, 32.4% with double, and 40.1% with triple vessel CAD). In multivariable analysis, there was a significant association between prevalent AF and coronary artery status (OR 0.64, 95% CI 0.53‐0.78, P trend?P trend = .005). Compared to single vessel CAD, the risk of AF was lower in double (OR 0.42, 95%CI 0.19‐0.95, P = .037) and triple CAD (OR 0.31, 95%CI 0.13‐0.71, P = .006). Finally, no association was found between AF prevalence and CAD origin among patients with single vessel CAD.ConclusionIn the LIFE‐Heart Study, CAS but not CAD was associated with increased risk of AF. |
| Keywords: | atrial fibrillation CAD extent CAD origin coronary artery disease coronary artery sclerosis prevalence |