真菌感染在过敏性皮炎发病机制中的作用

目的探讨真菌感染以及真菌特异性IgE对过敏性皮炎的致病作用。方法采用Bio whittaker变态反应诊断仪检测136例过敏性皮炎患者血清真菌特异性IgE(sIgE),将其分为两组:真菌感染组96例,为合并真菌感染的过敏性皮炎患者,其中荨麻疹45例,湿疹30例,特应性皮炎21例;对照组40例,来自无合并真菌感染的过敏性皮炎患者。结果真菌感染组中,血清真菌sIgE阳性率为87.5%(84/96),显著高于对照组(14/40,阳性率35.0%),血清真菌sIgE检出率在两组病人中差异有显著性意义(χ2=38.08,P<0.005),真菌感染组荨麻疹、湿疹、特应性皮炎患者血清真菌sIgE的阳性检出率差异无显著性意义(χ2=2.24,P>0.05)。结论真菌感染灶中真菌可能成为变应原刺激机体产生特异性IgE,真菌感染在过敏性皮炎的发病机制中占重要地位。

Fungus infection play a important role in the pathogenesis of allergic dermatitis

Objective To investigate the roles of fungus infection and fungus-specific IgE(sIgE) antibodies in the pathogenesis of allergic dermatitis. Methods The study was performed at 96 patients with fungus infection suffering from urticartia (45 cases), eczema (30 cases), atopic dermatitis (21 cases), respectively, and 40 allergic dermatitis patients without fungus infection as control group. The serum of suspected patients were collected, and the concentration of fungal sIgE antibodies were measured by allergy diagnostic apparatus(Biowhittaker, American).Results The sungal sIgE antibody positive rate was 87.5% in fungus infection group, which was evidently higher than that of control group (35.0%). The Chi-square test confirmed the influence of fungus infection without statistical significance among urticartia, eczema and atopic dermatitis in fungus infection group (P>0.05). Conclusion The results suggested that specific IgE antibodies of the fungus may play a important role in pathogenesis of allergic dermatitis.