低温等离子体对丝素纤维人工血管材料蛋白吸附性能的影响

丝素纤维是一种天然蛋白质纤维,具有良好的生物相容性,在生物医用材料领域具有广阔的应用前景。该文分别采用氦气和氧气低温等离子体处理丝素纤维人工血管材料,探究不同等离子体对材料表面形貌、亲水性、力学性能及蛋白吸附性能的影响。结果表明,两种等离子体均可对丝素纤维表面产生刻蚀作用,且氧气等离子体的刻蚀作用较强。然而,氦气等离子体对改善材料表面亲水性效果较优。拉伸断裂强度结果显示,氧气等离子体对丝素纤维人工血管材料的力学性能损伤较大。蛋白吸附试验结果显示,两种等离子体均能降低血浆蛋白在材料表面的吸附,且氦气等离子体处理的效果更为显著。本研究结果表明,采用氦气等离子体处理丝素纤维人工血管材料,可能更有助于减少血细胞在材料表面的粘附,从而降低形成血栓的风险,且对材料力学性能影响不大。

Effects of Low-temperature Plasma on Protein Adsorption of Silk Fibroin Fiber Fabric for Vascular Graft

Silk fibroin fiber is natural fiber of protein which has satisfactory biocompatibility and promising potential in a wide range of utilization in biomaterial field.In present work, both He and O2 plasma were used to treat silk fibroin fiber fabrics for vascular grafts, then the effects of the plasma on the morphology, the hydrophilicity, the mechanical properties and the protein adsorption were studied.The results suggested that both plasma treatments could give rise to etching on the fabrics, and the etching effect of O2 plasma treatment was more obvious.However, the hydrophilicity of the fabric after He plasma treatment was significantly improved.Moreover, the tensile force at break of the fabric after O2 plasma treatment decreased more than that of the fabric after He plasma treatment.Furthermore, the protein adsorption of the fabrics declined after both plasma treatments, but the amount of protein adsorbed on the surface of the fabrics treated by He plasma showed lower than that of the fabric after O2 plasma treatment.In summary, He plasma might be better than O2 plasma for decreasing the adsorption of blood cells onto the fabrics and the risk of thrombosis in vivo and maintaining the satisfactory mechanical property.