Enhanced development of morphine tolerance in rats treated with 2-deoxy-d-galactose |
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Authors: | P. Richter W. Pohle G. Grecksch K. H. Smalla R. Jork H. Matthies |
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Affiliation: | (1) Institute of Neurobiology and Brain Research, Brenneckestrasse 6, 0-3090 Magdeburg, Federal Republic of Germany;(2) Institute of Pharmacology and Toxicology, Medical Academy Magdeburg, Leipziger Strasse 44, 0-3090 Magdeburg, Federal Republic of Germany |
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Abstract: | Rats treated subcutaneously for 6 days with morphine developed a weak tolerance which was characterized by a decrease in the analgesic action of the opioid. Under those experimental conditions a simultaneous intracerebroventricular application of 2-deoxy-d-galactose enhanced development of morphine tolerance, while other deoxy-sugars like 2-deoxy-d-glucose and 6-deoxy-d-galactose were ineffective. In contrast, no influence of 2-deoxy-d-galactose on a more enhanced morphine tolerance after a 11-day pretreatment with morphine was found. The results are discussed in the light of a rather specific interference of 2-deoxy-d-galactose with neuronal glycoprotein processing and related cellular mechanism underlying adaptive processes involved in the development of morphine tolerance. |
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Keywords: | Rat Morphine tolerance 2-Deoxy- font-variant:small-caps" >d-galactose Glycoprotein synthesis Adaptive processes |
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