Réactions cutanées paradoxales sous traitement par tocilizumab |
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| Authors: | L. Sparsa N. Afif S. Bularca A. Fricker S. Thiebault E. Dahan D. Wendling J. Sibilia M. Ardizzone |
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| Affiliation: | 1. Service de rhumatologie, hôpital Émile-Muller, centre hospitalier de Mulhouse, 20, avenue du Docteur-Laennec, 68100 Mulhouse, France;2. Service de dermatologie, centre hospitalier de Mulhouse, hôpital Émile-Muller, centre hospitalier de Mulhouse, 20, avenue du Docteur-Laennec, 68100 Mulhouse, France;3. Service de pathologie, centre hospitalier de Mulhouse, hôpital Émile-Muller, centre hospitalier de Mulhouse, 20, avenue du Docteur-Laennec, 68100 Mulhouse, France;4. Service de rhumatologie, hôpital Jean Minjoz, CHRU de Besançon, 2, boulevard Fleming, 25030 Besançon, France;5. Service de rhumatologie, hôpital de Hautepierre, CHU de Strasbourg, 1, avenue Molière, 67098 Strasbourg France |
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| Abstract: | IntroductionTocilizumab (TCZ) is a humanized antihuman interleukin (IL)-6 receptor antibody recommended for the treatment of moderate to severe active rheumatoid arthritis, adult-onset Still disease, Castleman disease and more recently, systemic juvenile idiopathic arthritis. Like anti-TNFα, rituximab and less frequently abatacept, TCZ can induce paradoxical cutaneous eruption like psoriasis with predominantly palmoplantar presentation.Case reportWe report a 47-year-old woman with psoriastic arthritis who developed under anti-TNFα therapy and later under tocilizumab a paradoxical palmoplantar eruption.ConclusionThe specific underlying mechanisms of this side effect are unclear but relapse of these lesions seems to be observed with certain biological agents. |
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| Keywords: | Rhumatisme psoriasique Polyarthrite rhumatoï de Tocilizumab Effet paradoxal |
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