Sensory-predominant,painful, idiopathic neuropathy: inflammatory changes in sural nerves |
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Authors: | Kelkar Praful McDermott Wendy R Parry Gareth J |
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Affiliation: | Department of Neurology, 2 RCP, University of Iowa Hospitals, 200 Hawkins Drive, Iowa City, IA 52242, USA. praful-kelkar@uiowa.edu |
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Abstract: | Sensory-predominant, painful, idiopathic neuropathies are a common clinical problem. In this retrospective study of 11 patients with such a neuropathy, we found axonal loss in 9, with multifocal axonal loss in 4 patients; there were large perivascular mononuclear inflammatory infiltrates (>50 cells) in 4 and smaller infiltrates (10-20 cells) in 4. These findings suggest that some cases of this neuropathy may be due to autoimmune vasculopathy and therefore may respond to immunotherapy. |
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Keywords: | cryptogenic neuropathy idiopathic painful neuropathy idiopathic sensory neuropathy inflammatory neuropathy |
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