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| 格列齐特缓释片的研制及体外释放度考察 | |
| 引用本文： | 赵丽华,胡容峰,李华,李嘉煜,李师,梅康康.格列齐特缓释片的研制及体外释放度考察[J].中国药房,2006,17(18):1382-1384. |
| 作者姓名： | 赵丽华 胡容峰 李华 李嘉煜 李师 梅康康 |
| 作者单位： | 1. 安徽省现代中药研究中心,合肥市,230038;安徽中医学院药剂教研室,合肥市,230038;武警安徽总队医院药械科,合肥市,230041 2. 安徽省现代中药研究中心,合肥市,230038;安徽中医学院药剂教研室,合肥市,230038 3. 安徽省现代中药研究中心,合肥市,230038 |
| 摘 要： | 目的;制备格列齐特缓释片并考察其体外释放度。方法采用混合骨架材料制备格列齐特缓释片;参照进口格列齐特缓释片标准,采用紫外分光光度法,以pH7.4磷酸盐缓冲液900ml为溶剂,桨法测定本品释放度,并与参比制剂进行比较。结果所得缓释片体外释放度符合一级动力学规律,释放曲线经相似因子(f2)判断,与参比制剂相似。结论本品处方工艺稳定、重现性好,体外累积释放度符合要求。 |
| 关 键 词： | 格列齐特缓释片 制备 混合骨架材料 释放度 |
| 文章编号： | 1001-0408(2006)18-1382-03 |
| 修稿时间： | 2006年1月1日 |
Preparation and Dissolution of Gliclazide Sustained Release Tablets in Vitro |
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| ZHAO Lihua,HU Rongfeng,LI Hua,LI Jiayu,LI Shi,Mei Kangkang.Preparation and Dissolution of Gliclazide Sustained Release Tablets in Vitro[J].China Pharmacy,2006,17(18):1382-1384. | |
| Authors: | ZHAO Lihua HU Rongfeng LI Hua LI Jiayu LI Shi Mei Kangkang |
| Abstract: | OBJECTIVE:To prepare gliclazide sustained release tablets,and to evaluate its dissolution in vitro.METHODS:Mixed matrix materials was used to prepare the tablet.According to the standard of imported Gliclazide sustained release tablets,the dissolution was determined by UV-absorption spectrometry in release medium of900ml of phosphate buffer with pH value of7.4(paddle method).The results were compared with those of the reference preparation.RESULTS:The dissolution of the prepared tablet in vitro accorded with the first order kinetics law.The release curve was similar to that of reference preparation judging from similar agent(f 2 ).CONCLUSION:The formula of this preparation is stable in technology,good in reproduction quality,and presents a standard cumulative dissolution in vitro. |
| Keywords: | Gliclazide sustained release tablet Preparation Mixed matrix materials Dissolution |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |