可吸收高强度左旋聚丙交酯螺钉内固定兔股骨髁截骨

目的 应用新式可吸收材料的增强技术-固态压缩法制得高强度可吸收左旋聚丙交酯(SC-PLLA)螺钉。通过观察其固定动物股骨髁截骨后骨折愈合和组织反应，评估该装置的固定效能和生物相容性。方法 12只新西兰免于右侧股骨髁横向截骨，单枚SC-PLLA螺钉固定。术后4、8、12、36周处死，行放射学和组织学检查。结果 所有截骨周围均能明显地观察到骨痂，未见明显畸形。镜下见截骨愈合为骨性连接，骨组织可与PLLA直接接触。结论 SC-PLLA对承重松质骨的固定可靠，并且牛物相容性良好。

Absorbable high-strength poly-L-lactide screws in internal fixation of femoral condylar osteotomy in rabbits

Objective To assess the fixation efficiency and biocompatibility of the absorbable high strength poly L lactide (SC PLLA) screws which were designed and made by us through a new material reinforcement process, solid state compression (SC), by investigating the healing and tissue reaction of the rabbits which were given femoral osteotomy and fixed with the screws. Method The right femoral condyles of 12 New Zealand rabbits were first cut off and then fixed with a SC PLLA screw. They were sacrificed at 4, 8, 12, and 36 weeks postoperatively to exam their femurs radiologically and histologically. Results At all the sites of osteotomy was seen obvious formation of bony callus. There were no significant displacements at all the operative sides. Histologically, bony union showed at the site of osteotomy and direct connection between the bone and the implants was observed. Conclusion SC PLLA screws can provide sufficient internal fixation for the load bearing cancellous bone, and possess excellent biocompatibility.