| 银杏叶提取物对庆大霉素耳毒性保护作用的实验研究 |
| |
| 引用本文： | 闫艾慧,姜学钧,郝帅. 银杏叶提取物对庆大霉素耳毒性保护作用的实验研究[J]. 中国医科大学学报, 2007, 36(2): 212-213 |
| |
| 作者姓名： | 闫艾慧 姜学钧 郝帅 |
| |
| 作者单位： | 中国医科大学附属第一医院耳鼻咽喉科,辽宁,沈阳,110001 |
| |
| 摘 要： | 目的:研究银杏叶提取物(Egb)对庆大霉素(GM)所致耳毒性的拮抗作用,探讨庆大霉素耳毒性作用机制。方法:健康豚鼠15只,随机分为3组,I组为生理盐水组;II组为庆大霉素(GM)组,造成损伤模型;III组为银杏叶提取物(Egb)和庆大霉素(Egb GM)组,观测3组豚鼠不同时期畸变产物耳声发射(DPOAE)的改变,TUNEL法检测3组豚鼠毛细胞凋亡。结果:Egb可以减轻耳蜗外毛细胞的损伤率(P<0.05),较少凋亡,降低庆大霉素所致的耳毒性。结论:Egh对庆大霉素所致的耳毒性具有拮抗作用。
|
| 关 键 词： | 银杏叶提取物 庆大霉素 凋亡 |
| 文章编号： | 0258-4646(2007)02-0212-02 |
| 修稿时间： | 2006-09-18 |
Protective effect of extract of Ginkgo Biloba on gentamicin-induced ototoxicity in guinea pigs |
| |
| YAN Ai-hui,JIANG Xue-jun,HAO Shuai. Protective effect of extract of Ginkgo Biloba on gentamicin-induced ototoxicity in guinea pigs[J]. Journal of China Medical University, 2007, 36(2): 212-213 |
| |
| Authors: | YAN Ai-hui JIANG Xue-jun HAO Shuai |
| |
| Affiliation: | Department of Otolaryngology,The First Affdiated Hospital, China Medical University, Shenyang 110001, China |
| |
| Abstract: | Objective:To study the protective effect of the extract of Ginkgo Biloba(Egb) on gentamicin-induced ototoxicity.Methods:Fifteen guinea pigs were randomly divided into 3 groups,in which the guinea pigs were peritoneally injected with normal saline(saline group),gentamicin(gentamicin group),and both gentamicin and Egb(Egb GM group).Distort production of otoacoustic emission(DPOAE) thresholds were measured before and after the injection.The apoptosis of hair cells were detected by TUNEL method.Results:Compared with other 2 groups,the hair cell apoptosis and hearing thresholds were significant lower in Egb GM group(P < 0.05).Conclusion:Egb has protective effect against gentamicin-induced ototoxicity. |
| |
| Keywords: | extract of Ginkgo Biloba gentamicin apoptosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
