| 悦肝胶囊对四氯化碳损伤原代培养大鼠肝细胞的保护作用 |
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| 引用本文： | 蔡英兰,金政,朴丽花,李相伍,金美善. 悦肝胶囊对四氯化碳损伤原代培养大鼠肝细胞的保护作用[J]. 时珍国医国药, 2006, 17(11): 2141-2142 |
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| 作者姓名： | 蔡英兰 金政 朴丽花 李相伍 金美善 |
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| 作者单位： | 延边大学基础医学院人体解剖与组织胚胎学教研部,吉林,延吉,133000 |
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| 基金项目： | 吉林省延边朝鲜族自治州科技攻关资助项目（No.200206） |
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| 摘 要： | 目的探讨悦肝胶囊对四氯化碳(CC l4)损伤原代培养大鼠肝细胞的保护作用。方法以CC l4诱导大鼠肝细胞损伤模型,观察悦肝胶囊对肝细胞的琥珀酸脱氢酶(SDH)、酸性磷酸酶(ACPase)、葡萄糖-6-磷酸酶(G-6-Pase)活性和糖原含量以及肝细胞形态结构的影响。结果悦肝胶囊能显著提高SDH、G-6-Pase活性及糖原含量,抑制ACPase活性,并可显著改善受损肝细胞的形态结构变化。结论悦肝胶囊对CC l4损伤原代培养大鼠肝细胞具有保护作用。
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| 关 键 词： | 悦肝胶囊 肝损伤 大鼠 肝细胞 |
| 文章编号： | 1008-0805（2006）11-2141-01 |
| 收稿时间： | 2006-03-20 |
| 修稿时间： | 2006-06-21 |
Protective Effects of Yuegan Capsule on CCl4-induced Injury of Primary Cultured Rat Hepatocytes |
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| CAI Ying-lan,JIN Zheng,PIAO Li-hua,LI Xiang-wu,JIN Mei-shan. Protective Effects of Yuegan Capsule on CCl4-induced Injury of Primary Cultured Rat Hepatocytes[J]. Lishizhen Medicine and Materia Medica Research, 2006, 17(11): 2141-2142 |
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| Authors: | CAI Ying-lan JIN Zheng PIAO Li-hua LI Xiang-wu JIN Mei-shan |
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| Affiliation: | Department of Hunan Anatomy and Histology and Embryology, College of Basic Medicine, Yanbian University Yanfi 133000, China |
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| Abstract: | Objective To investigate the effects of Yuegan Capsule on CCl4-intoxicated primary cultured rat hepatocytes. Methods Hepatocytes injury models were induced by CCl4 in rats in vitro, and treated with Yuegan capsule. Structure of rat hepatocytes and effect of SDH,ACPase,G-6-Pase activeties and amount of hepatic glycogen were observed. Results The Yuegan Capsule increased the activity of SDH, G-6-Pase and the amount of hepatic glycogen, and restrain the activity of ACPase, and could improvc the changes of rat hepatocytes structure. Conclusion Yuegan capsule has protective effects on CCl4-induced injury of primary cultured rat hepatocytes. |
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| Keywords: | Yuegan Capsules Liver failure Rats Hepatocytes |
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