阻塞性睡眠呼吸暂停综合征患者代谢综合征的患病情况

目的分析阻塞性睡眠呼吸暂停综合征（OSAHS）患者中代谢综合征（MS）及其各构成组分的患病情况。方法对28例对照组和148例OSAHS组（46例轻度、35例中度和67例重度）的患者检测并分析形体参数和血液生化指标。结果（1）重度OSAHS组的HDL-C低于对照组和轻度OSAHS组（P〈0.05）;重度OSAHS组的FPG高于对照组（P〈0.05）;中重度OSAHS组的SBP高于对照组（P〈0.05）,重度OSAHS组的DBP高于对照组（P〈0.05）;重度OS-AHS组的BMI、腰围显著高于对照组、轻度和中度OSAHS组（P〈0.05-0.01）,中度OSAHS组的BMI、腰围显著高于对照组（P〈0.05-0.01）,轻度OSAHS组的腰围高于对照组（P〈0.05）;重度OSAHS组颈围高于对照组和轻度OSAHS组（P〈0.05）。（2）趋势χ^2检验显示四组肥胖、高血压、高血糖患病率间存在差异（P〈0.01-0.001）,且随着OSAHS程度的加重有升高趋势（P〈0.05-0.001）。（3）四组MS的患病率间存在差异（P〈0.01）,且随着OSAHS程度的加重有升高趋势（P〈0.05）。结论OSAHS尤其重度OSAHS组与MS的各主要症候密切相关,随着OSAHS程度的加重肥胖、高血压、高血糖和MS患病率有升高趋势。

Metabolism Syndrome in Patients with Obstructive Sleep Apnea-hypopnea Syndrome

Objective To explore the prevalence of metabolism syndrome （MS） and its components in patients with obstructive sleep apnea- hypopnea syndrome（OSAHS）. Methods Body mass index （BMI）, neck collar （NO）, waist circumference （WO）, blood pressure （BP）, plasma glucose and lipid profiles were measured and analyzed in 28 controls and in 148 OSAHS patients （46 mild, 35 moderate and 67 severe patients） . Results （1） HDL-C was lower in severe OSAHS group than that in control group and mild OSAHS group（P〈 0.05）. FPG was higher in severe OSAHS group than that in control group（P〈 0.05）. SBP was higher in moderate and severe OSAHS groups than that in control group（P 〈 0.05）. DBP was higher in severe OSAHS group than that in control group（P〈 0.05）. BMI and WO were significantly higher in severe OSAHS group than those in control group, mild and moderate OSAHS groups（P〈0.05 -0. 01）. BMI and WO were significantly higher in moderate OSAHS group than those in control group（P 〈 0.05-0.01）. WC was higher in mild OSAHS group than that in control group（P〈 0.05）. NC was higher in severe OSAHS group than that in control group and mild OSAHS group（P〈 0.05）. （2）The prevalence rates of obesity, hypertension and hyperglycemia were significantly different among the four groups, with a trend to gradually increase with the severity of OSAHS. （3）The prevalence rate of MS was significantly different among the four groups, with a trend to gradually increase with the severity of OSAHS. Conclusions There is a close correlation between OSAHS and MS, especially the severe OSAHS. The prevalence rates of obesity, hypertension, hyperglycemia and MS have a trend to gradually increase with the severity of OSAHS.