| 艾司唑仑与豆腐果苷素对大鼠血清NO的影响 |
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| 引用本文： | 王克林,崔成德,刘艳骄,李涢,袁朝阳. 艾司唑仑与豆腐果苷素对大鼠血清NO的影响[J]. 中国中医基础医学杂志, 2006, 12(2): 116-117 |
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| 作者姓名： | 王克林 崔成德 刘艳骄 李涢 袁朝阳 |
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| 作者单位： | 1. 中国中医科学院,中医基础理论研究所,北京,100700
2. 中国中医科学院,研究生院,北京,100700 |
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| 摘 要： | 目的:探讨催眠药与NO信息途径的相关性。方法:观察了口服艾司唑仑(舒乐安定)片与豆腐果苷素胶囊对SD大鼠血清NO的影响。结果:艾司唑仑片、豆腐果苷素胶囊分别连续4d给大鼠灌胃后,与空白对照组相比,艾司唑仑组大鼠血清NO水平升高51.2%,有显著性差异(P<0.05),豆腐果苷素组大鼠血清NO水平升高24.1%,但未见显著性差异(P>0.05)。提示:艾司唑仑片的镇静、催眠作用与NO信息途径相关,此相关性需要以45mg/kg/d,连续给药4d以上方能表现出来。
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| 关 键 词： | 艾司唑仑 豆腐果苷素 镇静催眠作用 |
| 文章编号： | 1006-3250（2006）02-0116-02 |
| 收稿时间： | 2005-07-14 |
| 修稿时间： | 2005-07-14 |
Effect on NO in Sera of Rats with Estazolam or Hilicide Capsule |
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| WANG Ke-lin,CUI Cheng-de,LIU Yan-jiao,LI Yun,YUAN Zhao-yang. Effect on NO in Sera of Rats with Estazolam or Hilicide Capsule[J]. Chinese Journal of Basic Medicine In Traditional Chinese Medicine, 2006, 12(2): 116-117 |
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| Authors: | WANG Ke-lin CUI Cheng-de LIU Yan-jiao LI Yun YUAN Zhao-yang |
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| Affiliation: | 1. Institute of Basic Theory, China Academy of Traditional Chinese; 2. Medicine(TCM |
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| Abstract: | Objective:The correlation between soporific and NO signal system was discussed.Methods:NO level was determined in sera of SD rats with oral Estazolam tablets or Hilicide capsule.Results:Comparing with control group,NO level is 51.2% high in the group with Estazolam tablets for 4 days.The difference between them is significant(P<0.05).It is 24.1% high in the group with Hilicide capsule,however the difference is no significant(P>0.05).Indication:The soporific action of Estazolam is correlated with NO signal system.It is obvious after Estazolam being taken orally 45 mg/kg per day for 4 days. |
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| Keywords: | Sleep NO Estazolam Hilicide |
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