颈动脉粥样硬化斑块与脑梗死关系的研究

目的:研究颈动脉粥样硬化斑块与脑梗死发生的关系,以及血脂、血糖、纤维蛋白原(Fbg)等在颈动脉粥样硬化形成中的影响。方法:对51例脑梗死病人行颈动脉超声检查,按有无粥样硬化斑块分成两组,比较其神经功能缺损情况及血液中TC、TG、LDL、HDL-C、apoprotein Al、apoprotein B、空腹血糖(FBG)和Fbg的含量;观察梗死侧与非梗死侧的颈动脉粥样硬化斑块发生率。结果:脑梗死病人的颈动脉粥样硬化斑块发生率为70.6％,与无斑块组比较,两组的神经功能缺损评分差异元显著性(P>0.05)。斑块组TC、LDL、aporprotein B、FBG及Fbg较无斑块组增高(P<0.05),HDL-C的含量则降低(P<0.05);梗死侧颈动脉粥样硬化斑块发生率增高(P<0.05)。结论:定期颈动脉超声和对血脂血糖等检查,可作为早期发现和筛选脑梗死高危病人的重要手段。

Investigation the Coreelation of Carotid Plaque and Cerebral Infarction

Objective: Investigation the correlation of carotid plaque and cerebral infarction, and the effecting of serum lipid, blood glucose and fibrinogen etc in carotid atherosclerosis plaque. Methods: 51 patients who suffered cerebral infarction were divided into carotid plaque group and no plaque group by ultrasonography, the states of neurologic impairment amd the content of serum cholesterol (TC) , triglycerides (TG) , low density lipoprotein (LDL), high-density lipoproteir cholesterol(HDL-C) , apoprotein Al, apoprotein B and fasting blood glucose(FBG) , fibrinogen (Fbg) in two group patients were comared. Observation the incidence of carotid plaque in infarct side and no infarct side. Results: The incidence of carotid plaque was 70.6% in cerebral infarction patients. The scores of neurologic impairment are no significant difference in two groups ( P > 0.05) , the contents of TC, LDL, apoprotein B, FBG and in Fbg plaque group is higher than no plaque group( P < 0.05 ) , the content of HDL-C is lower ( P < 0.05). The incidence of carotid plaque in infarct side is increased( P < 0.05). Conclusion: Regular examination of carotid ultrasound, serum lipid and blood glucose are important method which can earlier detect and screening the patients of cerebral infarction.