黄芪对致敏大鼠气道壁转化生长因子β_1、Ⅲ型胶原和纤维连接蛋白表达的影响 |
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引用本文: | 杜永成,许建英,秦芳,韩葆芬.黄芪对致敏大鼠气道壁转化生长因子β_1、Ⅲ型胶原和纤维连接蛋白表达的影响[J].中国中西医结合杂志,2005(Z1). |
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作者姓名: | 杜永成 许建英 秦芳 韩葆芬 |
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作者单位: | 山西医科大学第一医院呼吸科 太原030001 |
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基金项目: | 山西省科技攻关资助项目(No.021067) |
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摘 要: | 目的探讨黄芪在致敏大鼠气道重塑中的作用。方法Wistar雄性大鼠24只,随机分为对照组、致敏组和黄芪干预组,每组8只。采用卵蛋白腹腔注射致敏动物,2周后用1%卵蛋白雾化吸入激发。黄芪干预组在每日激发前给予黄芪注射液5g/kg腹腔注射。对照组以生理盐水代替卵蛋白雾化吸入和腹腔注射。分别采用免疫组化和原位杂交法测定大鼠气道壁Ⅲ型胶原、纤维连接蛋白(FN)及上皮细胞TGF-β_1蛋白水平和TGF-β_1mRNA表达水平。结果(1)致敏组大鼠气道壁Ⅲ型胶原、FN表达分别为29.49±1.89、25.98±1.53,与对照组(16.53±1.20、9.37±1.11)比较,差异有显著性(P<0.01);黄芪干预组(21.24±1.38、19.57±1.36)与致敏组比较,差异有显著性(P<0.01),但高于对照组(P<0.01)。(2)致敏组大鼠气道上皮细胞TGF-β_1蛋白和mRNA表达分别为26.99%±2.90%、24.91%±2.88%,与对照组(12.02%±1.52%、5.45%±1.18%)比较,差异有显著性(P<0.01);黄芪干预组(19.89%±2.06%、12.33%±1.34%)与致敏组比较,差...
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关 键 词: | 气道重塑 Ⅲ型胶原 纤维连接蛋白 转化生长因子-β1 黄芪 |
Effect of Astragalus Injection on Expression of Transforming Growth Factor-beta 1 and CollagenⅢand Fibronectin in Airway Wall of Sensitized Rats |
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Authors: | DU Yong-cheng XU Jian-ying QIN Fang |
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Abstract: | Objective To investigate the effect of astragalus injection(AGI)on airway remodeling in sensi- tized rats.Methods Twenty-four Wistar male rats were randomly divided into the control group(CG),the sensi- tized group(SG)and the AGI treated group(AG),with eight rats in each group.The sensitized rats model were established by intraperitoneal injection with ovalbumin,and to provoke the asthmatic attack two weeks later with 1% ovalbumin aerosol inhalation.AGI was given at a dose of 5g/kg with intraperitoneal inje... |
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Keywords: | airway remodeling collagenⅢ fibronectin transforming growth factor-beta 1 Astragalus |
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