Effects of the anticonvulsant lamotrigine and carbamazepine on synaptic transmission in the CA1 area of rat hippocampal slices |
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| Authors: | S. V. Kalemenev E. S. Kosacheva A. V. Sem'yanov O. V. Godukhin K. S. Raevskii |
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| Affiliation: | (1) Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino;(2) Laboratory of Neurochemical Pharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | Lamotrigine and carbamazepine (10−3 M) almost completely inhibit electrical activity of neurons in hippocampal slices. The effect of these drugs on signal transmission in the system of Schaffer collaterals/commissural fibers—CA1 hippocampal area pyramidal neurons shows that both anticonvulsants inhibit the excitability of the presynaptic axons and transmission efficiency in the glutamatergic synapses without any significant influence on signal transmission from a synapse to the spike generator region in the postsynaptic pyramidal neurons. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 9, pp. 307–310, September, 1998 |
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| Keywords: | lamotrigine carbamazepine hippocamp glutamatergic synaptic transmission |
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