| p75神经营养素受体在新生和成年大鼠背根神经节中的不同表达 |
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| 引用本文： | 严志强,徐邦生,衣昕,胡亚娥.p75神经营养素受体在新生和成年大鼠背根神经节中的不同表达[J].南通医学院学报,2002,22(4):371-372. |
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| 作者姓名： | 严志强 徐邦生 衣昕 胡亚娥 |
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| 作者单位： | 南通医学院江苏省神经再生重点实验室,南通,226001 |
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| 摘 要： | 目的：研究神经生长因子低亲和力受体p75NTR在新生和成年大鼠背根经节中的表达，以探讨p75NTR在背根神经节神经元中的作用。方法：取新生和3月龄大鼠背根神经节，免疫组化ABC法观察p75NTR在神经元中分布和表达。结果：新生大鼠背根神经节中可见较多的p75NTR阳性反应神经元，免疫反应产物主要位于胞浆。成年大鼠背根神经节大多数神经元有p75NTR阳性免疫反应产物，主要位于细胞核。结论：p75NTR在新生和成年大鼠背根神经节神经元中表现为不同表达方式，提示其在神经元发育和分化的不同阶段发挥着一定的作用。
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| 关 键 词： | p75神经营养素受体 背根神经节 大鼠 表达 |
| 文章编号： | 1000-2057(2002)04-0371-02 |
| 修稿时间： | 2002年9月2日 |
DIFFERENT EXPRESSION OF P75NTR IN NEURONS OF DRG FROM BOTH NEWBORN AND ADULT RAT |
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| YAN Zhiqiang,XU Bangsheng,YI Xin,et al.DIFFERENT EXPRESSION OF P75NTR IN NEURONS OF DRG FROM BOTH NEWBORN AND ADULT RAT[J].ACTA Academiae Medicinae Nantong,2002,22(4):371-372. |
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| Authors: | YAN Zhiqiang XU Bangsheng YI Xin |
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| Abstract: | Objective:To study the expression of low-affinity neurotrophin receptor p75NTR in dorsal root ganglion (DRG) of both newborn and adult rats. Methods:The expression and distribution of p75NTR in DRG of rats aged at newborn and 3 months old were visualized by ABC methods.Results:p75NTR-like immunohistochemical product, which was mainly located in the cytoplasm, was expressed in majority of neurons in DRG of newborn rats. However, p75NTR-like immunohistochemical product, which was mainly located in the nuclei, was seen in most of DRG neurons of adult rats. Conclusion:Different expression of p75NTR in neurons of DRG from both newborn and adult rat implies that p75NTR plays a role in development and differentiation of neurons? |
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| Keywords: | p75NTR Dorsal root ganglion(DRG) Rat |
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