幼年特发性关节炎的肾损害

幼年特发性关节炎(JIA)是影响多器官系统的全身性疾病,JIA并发肾损害丰要包括原发件肾损害、继发性肾淀粉样变性及药物性肾损害,常见的临床表现有蛋白尿、水肿、血尿、高血压及肾功能减退.治疗包括治疗原发病,抑制炎症反应,阻止肾淀粉样变,停用金制剂、青霉胺等肾损害药物及血液净化.幼年特发性关节炎全身型(SOJIA)合并巨噬细胞活化综合征(MAS)患儿出现严重肾脏损害,往往预后小良,早期、大剂量糖皮质激素单独或联合免疫抑制剂治疗,是决定预后的重要因素.

Renal compromise in childhood juvenile idiopathic arthritis

Juvenile idiopathic arthritis(JIA) is a multisystem disease characterized by persistent arthritis.Renal damage in JIA can be divided into primary nephropathy,secondary renal amyloidosis and drug-related nephropathy.Proteinuria,hematouria,edema,hypertension and renal dysfunction are common clinical manifestations.The management strategies include control of primary disease,inhibition of inflammation,discontinuation of associated drugs and blood purification.Renal involvement appears to be of poor prognosis i...