住院肺结核病人结核菌耐药性的动态观察

目的　分析和评价住院肺结核病人的耐药动态,为今后的结防工作提供参考依据。方法 收集本院不同年代(1982～1983,1990～1991和1997～1998年)住院病例,进行耐药率的分析。结果 原发耐药率分别为24.6%,35.1%和38.3%,原发耐多药率分别为3.5%,6.1%和12.3%。获得性耐药率分别为81.0%,65.8%和74.4%;获得性耐多药率分别为11.5%,16.6%和34.9%。原发耐药率、原发和获得耐多药率有逐年增长的趋势,获得性耐药率变化不大。结论 控制耐药的关键是实施NTP,统一化疗方案,广泛实施DOTS,做好耐药监测评价工作。

The trend of drug resistance for in-patient pulmonary tuberculosis

Objective　To analyse and evaluate the trend of antituberculosis drugs resistance for in-patient pulmonary tuberculosis for a better job of tuberculosis control.Methods　To collect in-patient cases in different years, i.e.1980～1981,1990～1991,1997～1998.The trend of drug resistance was analysed.Results　The prevalence of primary drug resistance was 24.6%,35.1% and 38.3% respectively in three periods.The prevalence of primary MDR-TB drug resistance was 3.5%,6.1% and 12.3% respectively.The prevalence of acquired drug resistance was 81.0%,65.8% and 74.4% respectively.The prevalence of acquired MDR-TB drug resistance was 11.5%,16.6% and 34.9% respectively.The perevalence of primary and acquired MDR-TB drug resistance was increasing but the prevalance of acquired drug resistance was almost steadily decreasing.Conclusion　The key of controlling drug resistance is to implement NTP,to standardize chemotherapy regimens,to implement DOTS,and to improve the evaluation work of drug resistance.