蛛网膜下腔出血后知浆t—PA、PAI—1变化的临床意义

对28例蛛网膜下腔出血（SAH）后患者的血浆组织型纤溶酶原激活物（t-PA）、纤溶酶原激活物抑制物（PAI-1）变化进行了观察，并与30例健康者进行对照。结果显示，与对照组比较，SAH后1～14天患者血浆纤溶性明显增高；其中伴发脑血管痉挛（CVS）者出血第7天、14天血浆PAI-1活性均明显高于无CVS者；出血量多者血浆t-PA、PAI-1活性较高。提示血浆t-PA、PAI-1活性在SAH后呈动态变化，二者可能均参与SAH的发生、发展、其活性测定可望成为监测SAH、CVS及出血量的有效指标。

Changcs and clinical value of plasrma t-PA and PAI of patients with subarachnoid hemorrahage

The plasma tissue-type plasminogen activator（t-PA），plasminogenactivator inhibitor-1（PAI-1）in 28 patients with subarachnoid hemorrhage（SAH） were observed and compared with 30 healthy controls.Result showed that the fibrinolytic activity of patients with SAH on day 1～14 were significantly higher than that of normal controls.Plasma PAI-1 activity of patients with cerebral vascular spasma（CVS） were higher than those without CVS on day 7，14.The more was the amount of bleeding，the more were the levels of t-PA and PAI-1.It suggests that the activity of plasma t-PA and PAI-1 are dynamic changing.Both of them may involve in the development and prognosis of SAH.Determination of t-PA and PAI-1 are efficient items for early finding，diagnosis of CVS and amount of bleeding in patients with SAH.