Hepatoprotective effect of rhinax on antitubercular drug-induced hepato-toxicity in rats |
| |
Authors: | Dhuley Jayant N |
| |
Affiliation: | Pharmacology and Toxicology Section, Research and Development Division, Hindustan Antibiotics Ltd., Pimpri, Pune 411 018, India. dr_jaynil@yahoo.com |
| |
Abstract: | Rhinax, a polyherbal formulation, exhibited hepatoprotective function when tested against antitubercular drug-induced hepatotoxicity in rats. Suppression of GSH and antioxidant enzymes "superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), gultathionle peroxidase (GPx) and glutathione S-transferase (GST) were noticed in the liver of antitubercular chemotherapeutic agents (namely isoniazid, rifampicin and pyrazinamide) treated animals accompanied with an increase in cytochrome P-450 contents and increased production of lipid peroxidation. Rhinax afforded hepatoprotection by inhibiting lipid peroxidation and, as a result, the animals showed improved antioxidant status. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|