微囊化雪旺细胞移植研究进展

微囊技术为组织 /细胞移植开辟了新途径 ,它有效地避免了移植后的免疫排斥反应 ,并解决了移植物来源稀少的问题。微囊具有良好的免疫隔离作用 ,体现在对免疫活性细胞及部分细胞因子的阻挡作用 ,使移植物能存活下来并发挥其功能。雪旺细胞的分离纯化技术已日渐成熟 ,目前对微囊化雪旺细胞的研究取得了一定的进展 ,使异种雪旺细胞的移植在治疗神经损伤方面成为可能 ,并具有广阔的应用前景。

The Advantage of Transplantation of Microencapsulated Schwann Cells

A large number of potential medical applica ti ons of microencapsulated cells have been developed, which is a possible approach to overcome the problems of human organ donor shortage in transplantation and p rovide effective protections against the immune rejective reaction, so it is imp ortant to develop immunoisolation systems for transplantation of xeno-or allogr afts. Some measures have been taken to prolong allo-or xenografts survivals. Th e techniques of isolation and purification of Schwann cells have been developed, and the remarkable progress was made in the research of microencapsulated Schwa nn cells. The transplantation of xeno-or allografts Schwann cells may be possib le rat for the treatment of nerve injury.