复苏犬心肌损伤的实验研究

目的：本实验通过研究复苏犬的心肌损伤，探讨心肌肌钙蛋白T对复苏犬心肌损伤的诊断价值。方法：利用犬室颤心跳呼吸骤停模型，进行标准心肺复苏，观察室颤前及复苏后犬血心肌肌钙蛋白T水平和心肌病理学变化。结果：在犬恢复自主循环1h后，血心肌肌钙蛋白T就明显升高，且其升高水平与病理学改变程度相对应。结论：（1）复苏犬存在急性心肌损伤；（2）心肌肌钙蛋白T血浓度能客观地反映心肌受损状态。

STUDY ON MYOCARDIAL INJURY IN RESUSCITATED DOGS

Aim: The experiment was conducted to study the myocardial injury in resuscitated dogs. Methods: The dogs with cardiac arrest model of ventricular fibrillation were used to be resuscitated with standard cardiopulmonary resuscitation. The levels of plasma cardiac troponin T (cTnT) before cardiac arrest and after restoration of spontanous circulation (ROSC) were measured. The variations of pathology and ultrastructure were observed.Results: Since 1 hour post-ROSC, the dogs' plasma cTnT levels had elevated. The levels of elevated cTnT were responsive to the degree of myocardial injury of pathology and ultrastructure of the resuscitated dogs. Conclusion:(1). Acute myocardial injuries were present in all resuscitated dogs. (2). The levels of plasma cTnT could objectively reflect the myocardial injury condition.